Search for a repressor regulator of invasion in Mycobacterium avium
ثبت نشده
چکیده
Mycobacterial species fill a wide variety of evolutionary niches. The most vigorously studied member of the genus is Mycobacterium tuberculosis, the causative agent of human tuberculosis (13). M. tuberculosis was responsible for an estimated 1.6 million deaths worldwide in 2002, making it second to only HIV in mortality attributed to an infectious disease (2). Mycobacterium bovis and Mycobacterium microti, causative agents of bovine and murine tuberculosis, respectively, along with M. tuberculosis and a few others make up an evolutionary clade of obligate pathogens of animals. Closely related are Mycobacterium marinum, a common pathogen of fish and frogs, and Mycobacterium ulcerans, responsible for Buruli’s ulcer (18).
منابع مشابه
Detection of Mycobacterium avium subsp. paratuberculosis in Cow Milk Using Culture and PCR methods
Mycobacterium avium subspecies paratuberculosis (MAP) is the cause of John’s disease also called paratuberculosis. This is economically one of the important infectious diseases in cattle and ruminant husbandry. This disease is manifested as granulomatosis entrocolitis, lymphadenitis and inflammation local lymphatic vessels. The typical sign of this disease is progressive loss of weight. Cons...
متن کاملDetection of Mycobacterium avium subsp. paratuberculosis in the mesenteric lymph nodes of goats by PCR and culture
The efficacy of bacterial cultures and IS900-specific polymerase chain reaction (PCR) was compared for the detection of Mycobacterium avium subsp. paratuberculosis (MAP) from the mesenteric lymph nodes of goats. Samples were collected from 75 goats slaughtered in Ilam, in southwest of Iran. Tissue homogenates were inoculated onto four media. The genomic DNA was extracted directly from mesenteri...
متن کاملNo holes barred: invasion of the intestinal mucosa by Mycobacterium avium subsp. paratuberculosis.
The infection biology of Mycobacterium avium subsp. paratuberculosis has recently crystallized, with added details surrounding intestinal invasion. The involvement of pathogen-derived effector proteins such as the major membrane protein, oxidoreductase, and fibronectin attachment proteins have been uncovered. Mutations constructed in this pathogen have also shed light on genes needed for invasi...
متن کاملMycobacterium avium subsp. paratuberculosis induces differential cytosine methylation at miR-21 transcription start site region
Mycobacterium aviumsubspecies paratuberculosis (MAP), as an obligate intracellular bacterium, causes paratuberculosis (Johne’s disease) in ruminants. Plus, MAP has consistently been isolated from Crohn’s disease (CD) lesions in humans; a notion implying possible direct causative ...
متن کاملPhenotypic and genomic analyses of the Mycobacterium avium complex reveal differences in gastrointestinal invasion and genomic composition.
Mycobacterium avium and Mycobacterium intracellulare are closely related organisms and comprise the Mycobacterium avium complex. These organisms share many common characteristics, including the ability to cause life-threatening respiratory infections in people with underlying lung pathology or immunological defects and occasionally in those with no known predisposing conditions. However, the ab...
متن کامل